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förster resonance energy transfer fret based akt activity reporter lyn aktar2 ev  (Addgene inc)


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    Addgene inc förster resonance energy transfer fret based akt activity reporter lyn aktar2 ev
    Förster Resonance Energy Transfer Fret Based Akt Activity Reporter Lyn Aktar2 Ev, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/förster resonance energy transfer fret based akt activity reporter lyn aktar2 ev/product/Addgene inc
    Average 93 stars, based on 4 article reviews
    förster resonance energy transfer fret based akt activity reporter lyn aktar2 ev - by Bioz Stars, 2026-06
    93/100 stars

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    Image Search Results


    Effect of BCR KO on proliferation of GCB-DLBCL lines correlates with reduction in AKT activity. (A) Correlation between relative proliferation after BCR KO in GCB-DLBCL lines, as calculated by the ratio (BCR-KO/BCR replete) of their absolute growth curve slopes, and the BCR KO–induced log2 change in HRK expression. For each cell line, the average value of 2 to 4 biological replicates (each with a different IgH-targeting gRNA) is displayed. (B) Correlation for GCB-DLBCL lines between BCR KO–induced reductions in proliferation and AKT activity, measured by FRET efficiency with the Lyn-AktAR2 reporter. AKT activity reduction value is the average of 3 biological replicates, each with a different IgH-targeting gRNA. (C) Relative decline of KO cells in GCB-DLBCL lines after IgH-targeting KO of BCR (upper panel) or combined KO of all 3 AKT genes (lower panel). Values shown are the mean ± SD from 2 (BCR KO) or 3 (AKT KO) biological replicates. (D) Relative decline of BCR-KO cells in DLBCL lines that are either unmodified or have previously undergone PTEN KO. Values shown are the mean ± SD from 3 biological replicates.

    Journal: Blood

    Article Title: Tonic B-cell receptor signaling in diffuse large B-cell lymphoma

    doi: 10.1182/blood-2016-10-747303

    Figure Lengend Snippet: Effect of BCR KO on proliferation of GCB-DLBCL lines correlates with reduction in AKT activity. (A) Correlation between relative proliferation after BCR KO in GCB-DLBCL lines, as calculated by the ratio (BCR-KO/BCR replete) of their absolute growth curve slopes, and the BCR KO–induced log2 change in HRK expression. For each cell line, the average value of 2 to 4 biological replicates (each with a different IgH-targeting gRNA) is displayed. (B) Correlation for GCB-DLBCL lines between BCR KO–induced reductions in proliferation and AKT activity, measured by FRET efficiency with the Lyn-AktAR2 reporter. AKT activity reduction value is the average of 3 biological replicates, each with a different IgH-targeting gRNA. (C) Relative decline of KO cells in GCB-DLBCL lines after IgH-targeting KO of BCR (upper panel) or combined KO of all 3 AKT genes (lower panel). Values shown are the mean ± SD from 2 (BCR KO) or 3 (AKT KO) biological replicates. (D) Relative decline of BCR-KO cells in DLBCL lines that are either unmodified or have previously undergone PTEN KO. Values shown are the mean ± SD from 3 biological replicates.

    Article Snippet: Förster resonance energy transfer (FRET) The FRET-based AKT activity reporter AktAR2 (Addgene) 12 was modified by N-terminal addition of the 10 N-terminal amino acids (AA) from Lyn kinase.

    Techniques: Activity Assay, Expressing